ObjectiveTo investigate the associations of white matter hyperintensity (WMH) burden and infarct volume with early neurological progression in anterior choroidal artery (AChA) territory infarction, and to identify potential imaging-based predictive thresholds.MethodsThis retrospective cohort study consecutively enrolled AChA infarct patients admitted to two comprehensive stroke centers between September 2018 and September 2024. WMH burden and infarct volume were assessed using the Fazekas visual

Repeatability of wide and standard macula scan measurements of macular thickness, and wide and standard disc scans for circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters.

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the leading causes of global blinding. More attention should be paid to the diagnosis, treatment and prognosis of DR. Swept-source optical coherence tomography angiography (SS-OCTA) is a novel imaging technique presented in recent years. It can accurately present the various levels of the retina, choriocapillaris, macula, and the optic papillary microcirculation, which is new to the diagnosis and progn

PurposePatients with Alzheimer’s Disease (AD) exhibit decreased retinal blood flow and vessel density (VD). However, it is not known whether these changes are also present in individuals with early AD (eAD) or amnestic type mild cognitive impairment (aMCI), an enriched pre-AD population with a higher risk for progressing to dementia. We performed a prospective case-control clinical study to investigate whether optical coherence tomography angiography (OCTA) parameters in the macula and disc are

Comparison of areas under the receiver operating characteristic curves (AUCs) between wide and standard macula scans of macular thickness parameters and between wide and standard disc scans of circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters for assessing glaucoma.

Zip file containing en-face OCTA choriocapillaris images of enrolled eyes.

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the leading causes of global blinding. More attention should be paid to the diagnosis, treatment and prognosis of DR. Swept-source optical coherence tomography angiography (SS-OCTA) is a novel imaging technique presented in recent years. It can accurately present the various levels of the retina, choriocapillaris, macula, and the optic papillary microcirculation, which is new to the diagnosis and progn

We collected data from 640 children aged 3-6 years who underwent routine vision examinations at the outpatient department of Peking University First Hospital between January 1 and June 30, 2025. We present EED-Astig, a new multimodal pediatric dataset for AI-based astigmatism severity prediction.The dataset is released as a single compressed file named `EED-Astig.zip`, which, upon extraction, reveals two main directories: **Images** and **Annotations**, along with an additional file **Parameter.

ProblemLow-quality fundus images with complex degredation can cause costly re-examinations of patients or inaccurate clinical diagnosis.AimThis study aims to create an automatic fundus macular image enhancement framework to improve low-quality fundus images and remove complex image degradation.MethodWe propose a new deep learning-based model that automatically enhances low-quality retinal fundus images that suffer from complex degradation. We collected a dataset, comprising 1068 pairs of high-qu

This observational study was approved by the Institutional Review Board of the Kyoto University Graduate School of Medicine (Kyoto, Japan) and adhered to the tenets of the Declaration of Helsinki. Written informed consent was obtained from each participant before initiating any study procedures or examinations. We included 14 healthy eyes of 14 healthy volunteers with no history or evidence of systemic and macula diseases. Each participant underwent high-resolution spectral-domain OCTA (OCT-A1,

PurposeDeep learning (DL) is a technique explored within ophthalmology that requires large datasets to distinguish feature representations with high diagnostic performance. There is a need for developing DL approaches to predict therapeutic response, but completed clinical trial datasets are limited in size. Predicting treatment response is more complex than disease diagnosis, where hallmarks of treatment response are subtle. This study seeks to understand the utility of DL for clinical problems

ABSTRACT Purpose: To determine the effects of vitamin D deficiency on retinal microvascularity using optical coherence tomography angiography. Methods: This study was designed as an observational case-control study. Ninety-eight eyes of patients with vitamin D deficiency and 96 eyes of healthy participants with serum vitamin D level >30 ng/mL were studied. Macula centered, 6.00 × 6.00 mm scan size images were taken. The vessel densities in the superficial and deep retinal capillary plexus, fov

PurposeTo investigate the relationship between nocturnal blood pressure (BP) dip and parapapillary choroidal vessel density (pCVD) in patients with normal-tension glaucoma (NTG)MethodsThis study analyzed 267 eyes of 267 untreated NTG patients who underwent 24-hour (h) intraocular pressure (IOP) and ambulatory BP monitoring in the habitual position. Patients were classified into 3 groups [non-dippers (nocturnal BP dip < 10%), dippers (nocturnal BP dip between 10% and 20%, and over-dippers (noctur

Comparison of the quantitative criteria used for the single superficial scans acquired with and without the Beam Expander (BE) module.

Qualitative criteria: comparison between single BE and averaged 3x3 mm scans.

Comparison of the quantitative criteria used for the single whole retina scans acquired with and without the beam expander (BE) module.

Comparison of the qualitative criteria used for the average scans acquired with and without the beam expander (BE) module.

Retinal thickness measurements of each retinal layer within the inner and outer retina, by retinal zone, and comparisons by Indigenous status.

AngioTool variables and descriptions [11].

Comparison of the qualitative criteria used for the single scans acquired with and without the beam expander (BE) module.

PurposeBlood flow (BF) of the retinal and choroidal vasculatures can be quantitatively imaged using MRI. This study sought to improve methods of data acquisition and analysis for MRI of layer-specific retinal and choroidal BF and then applied this approach to detect reduced ocular BF in a well-established mouse model of glaucoma from both eyes.MethodsQuantitative BF magnetic resonance imaging (MRI) was performed on glaucomatous DBA/2J and normal C57BL/6J mice. Arterial spin labeling MRI was appl

BackgroundThe cerebral and retinal circulation systems are developmentally, anatomically, and physiologically interconnected. Thus, we hypothesized that hypoperfusion due to atherosclerotic stenosis of the internal carotid artery (ICA) can result in disturbances of both cerebral and retinal microcirculations. We aimed to characterize parameters indicating cerebrovascular reactivity (CVR) and retinal microvascular density in patients with ICA stenosis, and assess if there is correlation between t

Mean total retinal thickness (TRT) across the entire 5 mm zone, and in each retinal zone for Aboriginal and/or Torres Strait Islander children and non-Indigenous children, and results of pairwise comparisons.

BackgroundThis study aims to use fundus image material from a long-term retinopathy follow-up study to identify problems created by changing imaging modalities or imaging settings (e.g., image centering, resolution, viewing angle, illumination wavelength). Investigating the relationship of image conversion factor and imaging centering on retinal vessel geometric characteristics (RVGC), offers solutions for longitudinal retinal vessel analysis for data obtained in clinical routine.MethodsRetinal

BackgroundTo explore the central and peripheral retinal and choroidal changes in diabetic patients without clinical diabetic retinopathy (DM-NoDR) using ultra-wide-field swept-source optical coherence tomography angiography (UWF-SS-OCTA).Methods67 DM-NoDR eyes and 32 age-matched healthy eyes were recruited. Retinal and choroidal parameters, including qualitative retinal microangiopathy, vessel flow (VFD) and linear density (VLD), thickness, and volume, were measured in the central and peripheral

PurposeRetinal function beyond foveal vision is not routinely examined in the clinical screening and management of diabetic retinopathy although growing evidence suggests it may precede structural changes. In this study we compare optical coherence tomography (OCT) based macular structure with function measured objectively with the ObjectiveFIELD Analyzer (OFA), and with Matrix perimetry. We did that longitudinally in Type 2 diabetes (T2D) patients with mild Diabetic Macular Oedema (DMO) with go

Correlations between preoperative SD-OCT, OCTA, visual field parameters, BCVA and postoperative MD.

ObjectiveTo report a case of torpedo maculopathy with multimodal fundus imaging methods, and apply the choroid vascularity index to quantitatively describe the choroidal structural changes in torpedo maculopathy.Case presentationAn asymptomatic 41-year-old Chinese woman with an incidentally found yellowish-white macular lesion in her left eye was referred to our hospital. She was unaware of any prior medical conditions. The best corrected visual acuity (BCVA) was 20/20 OD and 20/25 OS, respectiv

PurposeRecent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating between healthy and diseased eyes across multiple disease states is lacking. Here, we evaluate the sensitivity and specificity of FPF in discriminating between h

Purpose : To compare the relationship between macular ganglion cell layer (mGCL) thickness and 10-2 visual field (VF) sensitivity using different stimulus sizes in patients with temporal hemianopia from chiasmal compression. Methods: A cross-sectional study was conducted involving 30 eyes from 25 patients with temporal VF loss on 24-2 SITA standard automated perimetry due to previous chiasmal compression and 30 healthy

Retinal Vein Cannulation (RVC) is an emerging method for treating Retinal Vein Occlusion (RVO). The success of this procedure depends on surgeon expertise and, recently, robotic assistance. This paper proposes an autonomous RVC workflow leveraging deep learning and computer vision. Two Steady Hand Eye Robots (SHERs) control a 100-micrometer metal needle and a medical spatula to execute precise tasks. Three convolutional neural networks are trained to predict needle movement direction and iden

PurposeRetinal function beyond foveal vision is not routinely examined in the clinical screening and management of diabetic retinopathy although growing evidence suggests it may precede structural changes. In this study we compare optical coherence tomography (OCT) based macular structure with function measured objectively with the ObjectiveFIELD Analyzer (OFA), and with Matrix perimetry. We did that longitudinally in Type 2 diabetes (T2D) patients with mild Diabetic Macular Oedema (DMO) with go

PurposeRetinal function beyond foveal vision is not routinely examined in the clinical screening and management of diabetic retinopathy although growing evidence suggests it may precede structural changes. In this study we compare optical coherence tomography (OCT) based macular structure with function measured objectively with the ObjectiveFIELD Analyzer (OFA), and with Matrix perimetry. We did that longitudinally in Type 2 diabetes (T2D) patients with mild Diabetic Macular Oedema (DMO) with go

Coefficient of repeatability (CR) of choroidal thickness measurements using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT).

Choroidal thickness measurements using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT).

PurposeA hypercoagulable state has been reported to cause potential sight-threatening ischemia in patients suffering from Coronavirus disease 2019 (COVID-19). This study aimed to determine whether vessel density (VD), as measured by optical coherence tomography angiography (OCT-A), has insights into retinal and choriocapillaris vascular changes in patients affected by SARS-CoV-2 infection.MethodsHundred and fifty two patients positive for SARS-CoV-2 infection were enrolled in this observational,

Aims: To evaluate the repeatability of the peripapillary and macular vascular parameters using optical coherence tomography angiography (OCT-A) in healthy children. Materials and methods: Cross-sectional study including 34 eyes of 34 healthy children. After a complete medical examination, two consecutive OCT-A exams were done using AngioPlex Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA, USA) in the same session. The scan area used was 6 × 6 mm for the analysis of the superficial vascular plexus (

PurposeRecent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating between healthy and diseased eyes across multiple disease states is lacking. Here, we evaluate the sensitivity and specificity of FPF in discriminating between h

Differences in OCTA, SD-OCT, visual field parameters and BCVA before and after surgery via endoscopic endonasal approach.

Mean total retinal thickness (TRT) in each retinal zone and meridian, for all participants.

Demographic information and ocular biometric measures of the Aboriginal and/or Torres Strait Islander children and non-Indigenous children.

Purpose: To compare the morphologic characteristics and response to surgery of myopic foveoschisis (MF) with different patterns of vitreomacular interface abnormalities (VMIAs).Methods: In this observational case series, 158 eyes of 121 MF patients with epiretinal membrane (ERM) or vitreomacular traction (VMT) based on optical coherence tomography (OCT) were enrolled. All the eyes were divided into two groups by the pattern of VMIAs: ERM and VMT group. Sixty-one eyes underwent pars plana vitrect

Descriptive and clinical data and mean and standard deviation of peripapillary retinal nerve fiber layer thickness, for 40 early open-angle glaucoma eyes and 43 healthy control eyes, and comparison between groups.

Assessment of inner and outer retinal layer metrics on the cirrus HD-OCT platform in normal eyes. Comparison across quartiles.

Patients data are sequentially reported and grouped on the basis of their vitreoretinal interface disorder in: epiretinal membrane (ERM, stages 1 to 4), macular pseudohole and ERM with foveoschisis. (XLSX)

Perimetric and morphometric data considering β2-agAAb seropositivity: Mean defect (MD), retinal nerve fiber (RNFL), Bruchs’ membrane opening—minimum rim width (BMO-MRW), retinal ganglion cell (RGCL), inner nuclear layer (INL).

Two-sided t tests were performed when data was approximately normally distributed. Non-parametric Man-Whitney U-tests were performed, when data was not normally distributed.

Purpose: Ocular Surface squamous neoplasia (OSSN) is a broad entity encompassing a spectrum of squamous neoplasms of conjunctiva and cornea. This study aims to explore the utility of Artificial Intelligence (AI) models in detecting OSSN from slit lamp (SL) images. Methods: This is a retrospective observational study. Slit lamp (SL) images of OSSN disease, non-OSSN ocular surface lesions (OOSD) and normal ocular surfaces (N) were collected (2013-2023). Images with minimum resolution of 1024 x 102

PurposeRecent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating between healthy and diseased eyes across multiple disease states is lacking. Here, we evaluate the sensitivity and specificity of FPF in discriminating between h

Demographic data for total cohort and subdivided into glaucoma suspects and glaucoma patients: Age, gender, intraocular pressure at the day of examination with glaucoma therapy (IOP), number of antiglaucomatous eye drops, best corrected visual acuity (BCVA): Mean±SD; number family history of glaucoma, diabetes, hypertension.

PurposeThe aim was to analyze the association of subfoveal choroidal thickness (SFCT) with age, best-corrected visual acuity, refractive error, and axial length in Taiwan pediatric population.MethodsA total of 374 eyes in 187 children were enrolled in this retrospective cross-sectional comparative study, who underwent examinations of best-corrected visual acuity (BCVA), cycloplegic refraction, and axial length (AL). Subfoveal choroidal thickness was assessed utilizing spectral domain enhanced de

PurposeBlood flow (BF) of the retinal and choroidal vasculatures can be quantitatively imaged using MRI. This study sought to improve methods of data acquisition and analysis for MRI of layer-specific retinal and choroidal BF and then applied this approach to detect reduced ocular BF in a well-established mouse model of glaucoma from both eyes.MethodsQuantitative BF magnetic resonance imaging (MRI) was performed on glaucomatous DBA/2J and normal C57BL/6J mice. Arterial spin labeling MRI was appl

Female regression coefficient in multivariate analysis controlling for age with macular sectorial thickness values as outcome.

The tasks are binary diabetic retinopathy classification, three-class diabetic retinopathy state classification (normal, non-proliferative, and proliferative), diabetes mellitus prediction, and sex prediction.

The tomography of participants' right eyes measuring by optical OCT and rotating Scheimpflug imaging (OCULUS Pentacam ). A custom-built MATLAB code for automatic segmentation of corneal OCT images.

According to the data from the World Health Organization, patients with visual function disorders, such as amblyopia and intermittent exotropia, have increased significantly and become an important factor contributing to the global burden of disease.Currently, existing research has found that many human visual function disorders can be reflected in abnormal brain activities without ocular damage. The main clinical methods currently rely on subjective psychophysical tests and ophthalmological exa

BackgroundThe retina is a simple window to reflect the changes of brain nerves. The aim of this study was to investigate the association between retinal status and white matter lesions (WMLs) in 143 patients aged 50–80 years, utilizing Optical Coherence Tomography Angiography (OCTA) and the Fazekas Visual Scale for assessment.MethodsA total of 143 subjects underwent MRI scanning to assess the degree of WMLs using the Fazekas scale. Retinal imaging was conducted utilizing OCTA. Multivariate logis

Macular ganglion cell layer thickness distribution by age group, showing mean, first, fifth and 95th percentile values for each segment.

Purpose: To characterize anatomical dimensions of a disc notch using novel methods using spectral domain optical coherence tomography (SD-OCT). Participants: All age- and severity-matched glaucoma patients with disc notch (defined as complete loss of neural rim with no residual rim between disc and cup) seen from 2014 to 2015 who underwent enhanced depth imaging with SD-OCT (Cirrus HD-OCT version 6.5, Carl Zeiss, USA) were included for this retrospective observational study. Methods: Using known

Assessment of inner and outer retinal layer metrics on the cirrus HD-OCT platform in normal eyes, demographic features.

PurposeTo compare the quality of four OCT-angiography(OCT-A) modules.MethodThe retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was a

PurposeRecent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating between healthy and diseased eyes across multiple disease states is lacking. Here, we evaluate the sensitivity and specificity of FPF in discriminating between h

Purpose: To assess diffusion abnormalities of the optic nerve (ON) in giant cell arteritis (GCA) patients with acute onset of visual impairment (VI) using diffusion-weighted magnetic resonance imaging (DWI). Methods: DWI scans of GCA patients with acute VI were evaluated in a case-control study. Two blinded neuroradiologists assessed randomized DWI scans of GCA and controls for ON restricted diffusion. Statistical quality criteria and inter-

(XLSX)

Distribution of retina images according to diagnoses and anatomical criteria.

BackgroundThe retina and brain share a similar embryologic origin, blood barriers, and microvasculature features. Thus, retinal imaging has been of interest in the aging population to help in the early detection of brain disorders. Imaging evaluation of brain frailty, including brain atrophy and markers of cerebral small vessel disease (CSVD), could reflect brain health in normal aging, but is costly and time-consuming. In this study, we aimed to evaluate the retinal microvasculature and its ass

The study aimed to develop machine learning models that have strong prediction power and interpretability for diagnosis of glaucoma based on retinal nerve fiber layer (RNFL) thickness and visual field (VF). We collected various candidate features from the examination of retinal nerve fiber layer (RNFL) thickness and visual field (VF). We also developed synthesized features from original features. We then selected the best features proper for classification (diagnosis) through feature evaluation.

ObjectiveWe investigated the clinical efficiency and complications of treatment of retinal sub-inner limiting membrane (sub-ILM) hemorrhage by 577-nm semiconductive laser membranotomy.MethodsThe clinical features, ocular fundus photography, and SD-OCT image of patients who received 577-nm laser membranotomy for sub-ILM hemorrhage were assessed from January 2017 to April 2022 in this retrospective case-series study.ResultsA total of 19 patients (19 eyes) were treated for sub-ILM hemorrhage of the

The exploration of retinal vessel structure is colossally important on account of numerous diseases including stroke, Diabetic Retinopathy (DR) and coronary heart diseases, which can damage the retinal vessel structure. The retinal vascular network is very hard to be extracted due to its spreading and diminishing geometry and contrast variation in an image. The proposed technique consists of unique parallel processes for denoising and extraction of blood vessels in retinal images. In the preproc

IntroductionInfectious keratitis is a vision threatening disease. Bacterial and fungal keratitis are often confused in the early stages, so right diagnosis and optimized treatment for causative organisms is crucial. Antibacterial and antifungal medications are completely different, and the prognosis for fungal keratitis is even much worse. Since the identification of microorganisms takes a long time, empirical treatment must be started according to the appearance of the lesion before an accurate

PurposeThe study utilized wide-field swept-source optical coherence tomography angiography (SS-OCTA) to examine the alterations in retinal and choroidal blood flow in patients with end-stage renal disease (ESRD) before and after hemodialysis.MethodsForty-two eyes of 24 participants with end-stage renal disease were enrolled in this prospective and cross-sectional study. A full ophthalmic examination was conducted on each participant 1 h before and after hemodialysis, which included wide-field SS

Age-related macular degeneration (AMD) is a chronic multifactorial eye disease representing the primary cause of vision loss in people aged 60 years and older. The etiopathogenesis of the disease remains uncertain, with several risk factors contributing to its onset and progression, such as genotype, aging, hypertension, smoking, overweight, and low dietary intake of carotenoids. Since the aging populations of the industrialized world are increasing rapidly, the impact of AMD in the socio-econom

PurposeBlood flow (BF) of the retinal and choroidal vasculatures can be quantitatively imaged using MRI. This study sought to improve methods of data acquisition and analysis for MRI of layer-specific retinal and choroidal BF and then applied this approach to detect reduced ocular BF in a well-established mouse model of glaucoma from both eyes.MethodsQuantitative BF magnetic resonance imaging (MRI) was performed on glaucomatous DBA/2J and normal C57BL/6J mice. Arterial spin labeling MRI was appl

Abbreviations: OCT: Optical coherence tomography; RNFL: Retinal nerve fiber layer; TMV: Total macular volume; SD: Standard deviation.

PurposeBlood flow (BF) of the retinal and choroidal vasculatures can be quantitatively imaged using MRI. This study sought to improve methods of data acquisition and analysis for MRI of layer-specific retinal and choroidal BF and then applied this approach to detect reduced ocular BF in a well-established mouse model of glaucoma from both eyes.MethodsQuantitative BF magnetic resonance imaging (MRI) was performed on glaucomatous DBA/2J and normal C57BL/6J mice. Arterial spin labeling MRI was appl

PurposeTo investigate variation in reflectivity of choroidal layers in normal eyes.MethodsFrom the swept-source optical coherence tomography database, we retrospectively included eyes with a normal fundus. Choroidal reflectivity was measured on the horizontal and vertical B-scan optical coherence tomography images. The optical barrier of the choroid was defined as the first hill in the middle of the reflectance graph from the retinal pigment epithelium-Bruch’s membrane complex to the chorioscler

PurposeThe aim was to analyze the association of subfoveal choroidal thickness (SFCT) with age, best-corrected visual acuity, refractive error, and axial length in Taiwan pediatric population.MethodsA total of 374 eyes in 187 children were enrolled in this retrospective cross-sectional comparative study, who underwent examinations of best-corrected visual acuity (BCVA), cycloplegic refraction, and axial length (AL). Subfoveal choroidal thickness was assessed utilizing spectral domain enhanced de

PurposeRecent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating between healthy and diseased eyes across multiple disease states is lacking. Here, we evaluate the sensitivity and specificity of FPF in discriminating between h

Background/Aims: Neovascular age-related macular degeneration (nAMD) is frequently bilateral, and previous reports on ‘fellow eyes’’ have assumed sequential treatment after a period of treatment of the first eye only. The aim of our study was to analyse baseline characteristics and visual acuity (VA) outcomes of fellow eye involvement with nAMD, specifically differentiating between sequential and non-sequential (due to macular scarring in the first eye) anti-vascular endothelial growth

Macular retinal thickness distribution by age group, showing mean, first, fifth and 95th percentile values for each segment.

Area under the curve (AUC) for sectorial macula VD in SVP, ICP, and DCP (a) and glaucoma morphometric parameters (BMO-MRW, RNF (inner, middle, outer ring), GCL, INL, (b).

Purpose: To assess the influence of capsular tension ring (CTR) on surgical outcomes of toric and multifocal intraocular lenses (IOLs) in eyes at high risk of zonular instability. Methods: Fifty-five eyes of 43 patients who had undergone phacoemulsification and IOL implantation were included in the analysis. They had some risk of zonular weakness, such as pseudoexfoliation, shallow anterior cha

OBJECTIVES: To evaluate visual acuity (VA) outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) in diabetic macular oedema (DMO). METHODS: In this retrospective cohort study, electronic medical records for all patients undergoing intravitreal injections (IVI) in a tertiary referral centre between March 2013 and October 2018 were analysed. Treatment response in terms of visual acuity outcomes were reported for

Australian Bureau of Statistics Australian Standard Classification of Cultural and Ethnic Groups broad group classification of participants.

95% confidence intervals are shown in parentheses.

Assessment of inner and outer retinal layer metrics on the cirrus HD-OCT platform in normal eyes, metrics in entire cohort and sex breakdown.

BackgroundChronic cerebral hypoperfusion triggers the development of white matter hyperintensities (WMHs), common in cerebral small vessel disease (CSVD). However, conventional imaging techniques cannot visualize cerebral small vessels. The retina, a direct extension of the central nervous system, has an unclear correlation with WMHs. This study employs Optical coherence tomographic angiography (OCTA) to investigate vascular changes in the retina and explore its correlation with WMHs, aiming to

PurposeTo investigate the heritability of genetic influence on macular choroidal vascularity index (CVI).MethodsTotal choroidal area (TCA), luminal area (LA), and CVI was measured using horizontal scan of spectral-domain optical coherence tomography with enhanced depth imaging in the 373 healthy twin participants. Characteristics of the participants were investigated, including age, sex, axial length, hypertension, diabetes, drinking habits, and smoking status. Univariate and subsequent multivar

PurposeEarly detection, monitoring and understanding of changes in the retina are central to the diagnosis of glaucomatous optic neuropathy, and vital to reduce visual loss from this progressive condition. The main objective of this investigation was to compare glaucoma diagnostic accuracy of commercially available optical coherence tomography (OCT) devices (Zeiss Stratus, Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue, and Topcon 3D-OCT).Patients16,104 glaucomatous and 11,543 normal eyes

ABSTRACT Purpose: To determine the effects of vitamin D deficiency on retinal microvascularity using optical coherence tomography angiography. Methods: This study was designed as an observational case-control study. Ninety-eight eyes of patients with vitamin D deficiency and 96 eyes of healthy participants with serum vitamin D level >30 ng/mL were studied. Macula centered, 6.00 × 6.00 mm scan size images were taken. The vessel densities in the superficial and deep retinal capillary plexus, fov

Coefficients of repeatability of choroidal thickness measurements using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) in patients with choroidal thickness ≥ 400 μm (35 eyes).

Type III tests of fixed effects for SVP (a), ICP (b), and DCP (c): Diagnosis, OCT-A sector, age and the interaction diagnosis with sector is presented.

PurposeThe aim was to analyze the association of subfoveal choroidal thickness (SFCT) with age, best-corrected visual acuity, refractive error, and axial length in Taiwan pediatric population.MethodsA total of 374 eyes in 187 children were enrolled in this retrospective cross-sectional comparative study, who underwent examinations of best-corrected visual acuity (BCVA), cycloplegic refraction, and axial length (AL). Subfoveal choroidal thickness was assessed utilizing spectral domain enhanced de

Errors for original estimate and estimates after simple correction and after re-training.

IntroductionMachine learning technology has demonstrated significant potential in glaucoma research, particularly in early diagnosis, predicting disease progression, evaluating treatment responses, and developing personalized treatment strategies. The application of machine learning not only enhances the understanding of the pathological mechanism of glaucoma and optimizes the diagnostic process but also provides patients with accurate medical services.MethodsThis study aimed to describe the cur

Demographics and ocular data including macular ganglion cell layer plus inner plexiform layer (mGCIPL), mGCIPL plus nerve fiber layer (mGCC) and total retinal layer (TRL) measurements by swept source optical coherence tomography (SS-OCT) wide scan and standard macula scan, and circumpapillary retinal nerve fiber layer (cpRNFL) measurements by SS-OCT wide scan and standard disc scan of normal subjects and glaucoma patients.

Mean (a) and sectorial (1–12, b) vessel density in SVP, ICP, and DCP for controls, patients with OHT and pre-OAG.

*The range of MD values for study eyes included in the IIHTT was -7.00 to -2.00 dB, but fellow eyes were typically better than the study eye.

Columns H through BG correspond to the 54 points tested in a 24–2 visual field. Points 26 and 35 correspond to the physiologic blind spot and were omitted. (XLSX)

BackgroundThe extent of ischemic injury in acute stroke is assessed in clinical practice using the Acute Stroke Prognosis Early CT Score (ASPECTS) rating system. However, current ASPECTS semi-quantitative topographic scales assess only the middle cerebral artery (MCA) (original ASPECTS) and posterior cerebral (PC-ASPECTS) territories. For treatment decision-making in patients with anterior cerebral artery (ACA) occlusions and internal carotid artery (ICA) occlusions with large ischemic cores, me

Macular inner plexiform layer thickness distribution by age group, showing mean, first, fifth and 95th percentile values for each segment.

PurposeRecent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating between healthy and diseased eyes across multiple disease states is lacking. Here, we evaluate the sensitivity and specificity of FPF in discriminating between h

PurposeModalities for myopia control, such as orthokeratology, repeated low-intensity red light (RLRL) treatment, and low-concentration atropine, have become popular topics. However, the effects of these three modalities on ocular surface health remain unclear. The tear meniscus height (TMH), a crucial criterion for evaluating ocular surface health and diagnosing dry eye, is conventionally measured via manual demarcation of ocular surface images, which is inefficient and involves subjective judg

Mean and standard deviation of macular ganglion cell layer thickness obtained with horizontal and vertical scans in the control group and early glaucoma patients, and comparison between groups.

BackgroundThis study aimed to develop deep learning models using macular optical coherence tomography (OCT) images to estimate axial lengths (ALs) in eyes without maculopathy.MethodsA total of 2,664 macular OCT images from 444 patients’ eyes without maculopathy, who visited Beijing Hospital between March 2019 and October 2021, were included. The dataset was divided into training, validation, and testing sets with a ratio of 6:2:2. Three pre-trained models (ResNet 18, ResNet 50, and ViT) were dev

PurposeTo describe the retinal contour in optical coherence tomography (OCT) images, and report the relationship between retinal contour and axial length.MethodsRetinal contour was defined by the path of the retinal pigment epithelial (RPE) line in macular and extra-macular OCTs of 70 eyes of 70 participants recruited from ophthalmology clinics in South Australia. The shape of this contour was described by the best-fit curvature (K), and Fourier analysis of the difference between K and the RPE.

This study quantified and compared phase retardation distribution in the central macula with the thickness of the Henle fiber layer (HFL). A scanning laser polarimeter (SLP) was used to acquire 20° × 40° macular-centered images, either with fixed corneal compensation or with variable corneal compensation, in two cohorts of clinically normal subjects (N = 36). Phase retardation maps from SLP imaging were used to generate a macular cross pattern (fixed compensation) or an annulus pattern (variable

Assessment of inner and outer retinal layer metrics on the cirrus HD-OCT platform in normal eyes. Comparison to age.

ProblemLow-quality fundus images with complex degredation can cause costly re-examinations of patients or inaccurate clinical diagnosis.AimThis study aims to create an automatic fundus macular image enhancement framework to improve low-quality fundus images and remove complex image degradation.MethodWe propose a new deep learning-based model that automatically enhances low-quality retinal fundus images that suffer from complex degradation. We collected a dataset, comprising 1068 pairs of high-qu

Summary of the vessel variables with the p- values, showing the differences between DR and RVO groups.

Agreement between wide and standard macula scan measurements for macular thickness parameters, and wide and standard disc scan for circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters.

We describe a case of brolucizumab-related intraocular inflammation (IOI) detected using vitreous haze on optical coherence tomography (OCT) at an early stage before the patient was aware of any symptom. A 69-year-old female presented with decreased right vision. The patient was diagnosed with pachychoroidal neovasculopathy and started intravitreal aflibercept (IVA) with a 3+ treat-and-extend strategy (TAE). Although the serous retinal detachment (SRD) disappeared after IVA treatment, the patien

Background: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors.Methods: The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits using follow-up scans. Macular vessel density was calculated globally and in the nine early treatment diabetic retinopathy study (ETDRS) subfields of the macula superficial layer.Results: The macular

ABSTRACT Purpose: To describe microvascular changes in the maculas of individuals with type 2 diabetes observed on optical coherence tomography angiography (OCTA) images. We compared the maculas of diabetic subjects without diabetic retinopathy with those of healthy subjects and correlated the findings with the clinical profiles of diabetic subjects. Methods: One eye each of 30 patients with diabetes and 30 healthy individuals were examined. The patients with diabetes underwent funduscopy, ret

Statistical analysis of OCTA biomarkers on the 26-image dataset.

Myopic Choroidal neovascularization (mCNV) is one of the most common vision-threatening com- plications of pathological myopia among many retinal diseases. Optical Coherence Tomography Angiography (OCTA) is an emerging newer non-invasive imaging technique and is recently being included in the investigation and treatment of mCNV. However, there exists no standard tool for time-efficient and dependable analysis of OCTA images of mCNV. In this study, we propose a customizable ImageJ macro that auto

Myopic Choroidal neovascularization (mCNV) is one of the most common vision-threatening com- plications of pathological myopia among many retinal diseases. Optical Coherence Tomography Angiography (OCTA) is an emerging newer non-invasive imaging technique and is recently being included in the investigation and treatment of mCNV. However, there exists no standard tool for time-efficient and dependable analysis of OCTA images of mCNV. In this study, we propose a customizable ImageJ macro that auto

We explore the choroid vasculature changes of acute Vogt–Koyanagi–Harada (VKH) disease using widefield optical coherence tomography angiography (OCTA). In this retrospective, observational, longitudinal study, 16 patients with acute VKH disease (32 eyes, mean age: 42.19 ±13.66 years) were measured using widefield OCTA. In this study, we first described the multiple dark foci in choriocapillaris and Sattler’s layer in the panoramic montage of the five 12x12mm images in 30 eyes (93.8%) of acute VK

BackgroundSympathetic ophthalmia (SO) is a rare but sight-threatening uveitis, and most observations have been made after typical manifestations occur. This report focuses on the choroidal changes detected by multimodal imaging at the presymptomatic stage of SO, which is implicated in the early recognition of SO.Case presentationA 21-year-old woman suffered from decreased vision in the right eye and was diagnosed with retinal capillary hemangioblastomas associated with Von Hippel–Lindau syndrome

PurposeTo clarify the effects of acute hyperglycemia on the responses of choroidal structural components and vascularity index during light modulation in healthy participants using techniques including image binarization and artificial intelligence (AI) segmentation based on swept-source optical coherence tomography (SS-OCT).MethodsTwenty-four eyes of 24 healthy participants were imaged at different stages after ambient light, 40 min of dark adaptation, and 5 min of light adaptation in two imagi

BackgroundAdvanced neuroimaging use has increased in U.S. emergency departments (EDs), including for neuro-ophthalmic conditions requiring computed tomography (CT) or magnetic resonance imaging (MRI) and their use has shifted in recent years amid changing care patterns and the COVID-19 pandemic. To evaluate these changes, this study examined national trends of CT and MRI use for eye-related ED visits from 2016 to 2022.Materials and methodsA retrospective trend study was conducted using 2016–2022

Comparative table with open-access ophthalmological datasets.

The integration of artificial intelligence (AI) in diagnosing diabetic retinopathy, a major contributor to global vision impairment, is becoming increasingly pronounced. Notably, the detection of vision-threatening diabetic retinopathy (VTDR) has been significantly fortified through automated techniques. Traditionally, the reliance on manual analysis of retinal images, albeit slow and error-prone, constituted the conventional approach. Addressing this, our study introduces a novel methodology th

The integration of artificial intelligence (AI) in diagnosing diabetic retinopathy, a major contributor to global vision impairment, is becoming increasingly pronounced. Notably, the detection of vision-threatening diabetic retinopathy (VTDR) has been significantly fortified through automated techniques. Traditionally, the reliance on manual analysis of retinal images, albeit slow and error-prone, constituted the conventional approach. Addressing this, our study introduces a novel methodology th

Purpose To evaluate the predictive utility of quantitative imaging biomarkers, acquired automatically from optical coherence tomography (OCT) scans, of cross-sectional and future visual outcomes of patients with neovascular age-related macular degeneration (AMD) starting anti-vascular endothelial growth factor (VEGF) therapy. Design Retrospective cohort study. Methods  Automatic segmentation was ca

Purpose : To evaluate the accuracy of pre-operative biomicroscopy (BM), ultrasonography (US), and spectral domain optical coherence tomography (SD-OCT) for determining complete posterior vitreous detachment (PVD) confirmed by intraoperative findings of triamcinolone acetonide-assisted pars plana vitrectomy (PPV). Design : This was a prospective, consecutive, interventional case series.

Purpose: To characterize in vivo morphometry and multispectral autofluorescence of the retinal pigment epithelial (RPE) cell mosaic and its relationship to cone cell topography across the macula. Methods: RPE cell morphometrics were computed in regularly spaced regions of interest (ROIs) from contiguous short-wavelength autofluorescence (SWAF) and photoreceptor reflectance images collected across the macula in one eye of 10 normal participants (23–65 years) by using adaptive optics scanning l

This dataset contains high-resolution 3D confocal microscopy images of retinal ganglion cells (RGCs) from the retina of mole-rat models Fukomys mechowii and Fukomys anselli . The raw images were originally obtained as .tif files and later converted into. ims format for use with Imaris Software. The Imaris filament tracer extension was used to trace the dendritic structures of RGCs, while the soma surfaces were traced separately. These post-processed images are part of a study

Traditional biomarkers, such as those obtained from blood tests, are essential for early disease detection, improving health outcomes, and reducing healthcare costs. However, they often involve invasive procedures, specialized laboratory equipment, or special handling of biospecimens. The retinal age gap (RAG) has emerged as a promising new biomarker that can overcome these limitations, making it particularly suitable for disease screening in low- and middle-income countries. This study aimed

Dataset from the study "Changing trends in ophthalmological emergencies during the COVID-19 pandemic"

IntroductionUveal melanoma (UM) is the most common intraocular malignancy in adults. Plaque brachytherapy remains the dominant eyeball-conserving therapy for UM. Tumor regression in UM after plaque brachytherapy has been reported as a valuable prognostic factor. The present study aimed to develop an accurate machine-learning model to predict the 4-year risk of metastasis and death in UM based on ocular ultrasound data.Material and MethodsA total of 454 patients with UM were enrolled in this retr

PurposeTo compare the detection of non-perfusion areas (NPAs) in diabetic retinopathy (DR) using 24×20 mm widefield swept-source optical coherence tomography angiography (SS-OCTA) and ultra-widefield fluorescein angiography (UWFA), and to explore NPA distribution patterns.MethodsThis retrospective study included 64 eyes from 48 DR patients who underwent 24×20 mm SS-OCTA and UWFA examinations. NPAs were manually annotated, and the detection rates and distribution patterns across retinal quadrants

The retinal pigment epithelium (RPE) is vital for the healthy function of the retina. Cellular level changes in the RPE are not visualized with current clinical techniques due to a lack of spatial resolution. Fluorescence adaptive optics scanning light ophthalmoscopy (AOSLO) can image RPE cells by utilizing their intrinsic autofluorescence (AF). The RPE AF has been imaged with only a few discrete excitation and emission bands and the multi-spectral AF has not been interrogated systematically at

Non-confocal split-detection imaging reveals the cone photoreceptor inner segment mosaic in a plethora of retinal conditions, with the potential of providing insight to ageing, disease, and response to treatment processes, in vivo, and allows the screening of candidates for cell rescue therapies. This imaging modality complements confocal reflectance adaptive optics scanning light ophthalmoscopy, which relies on the waveguiding properties of cones, as well as their orientation toward the pupil.

A limitation of scanning laser ophthalmoscopy (SLO) is that eye movements during the capture of each frame distort the retinal image. Various sophisticated strategies have been devised to ensure that each acquired frame can be mapped quickly and accurately onto a chosen reference frame, but such methods are blind to distortions in the reference frame itself. Here we explore a method to address this limitation in software, and demonstrate its accuracy. We used high-speed (200 fps), high-resolutio

The study's objective is to evaluate the performance of a deep learning system (DLS) in classifying the severity of papilledema associated with increased intracranial pressure, on standard retinal fundus photographs. A DLS was trained to automatically classify papilledema severity in 965 patients (2103 mydriatic fundus photographs), representing a multiethnic cohort of patients with confirmed elevated intracranial pressure. Training was performed on 1052 photographs with mild/modera

ObjectiveTo establish a normative database for the vascular density (VD) in macular, disc, and peripapillary regions in healthy myopic children and to evaluate associated ocular features with optical coherence tomography angiography (OCTA).MethodsThis was an observational, prospective and cross-sectional study. 776 Chinese healthy myopic children (375 boys and 401 girls) were enrolled, mean (±SD) age 9.84 ± 1.98 (range 6–16) years. En-face angiogram OCTA was performed on 6 mm × 6 mm retinal and

Aim: The objective of the study was to investigate the evaluation indices (diagnostic test accuracy and agreement) of 15 combinations of ultrawide field scanning laser ophthalmoscopy (UWF SLO) images in myopic retinal changes (MRC) screening to determine the combination of imaging that yields the highest evaluation indices in screening MRC. Methods: This is a retrospective study of UWF SLO images obtained from myopes and were analyzed by 2 retinal specialists independently. Five field UWF SLO im

Confocal scanning laser ophthalmoscopy (cSLO) is a non-invasive technique for real-time imaging of the retina. We developed a step-by-step protocol for the semi-automatic evaluation of myeloid cells in cSLO images from CX3CR1GFP mice, expressing green fluorescent protein (GFP) under control of the endogenous CX3C chemokine receptor 1 locus. We identified cSLO parameters allowing us to distinguish animals with experimental autoimmune encephalomyelitis (EAE) from sham-treated/naïve animals. Especi

Vasculature morphology and hierarchy are essential for blood perfusion. Human retinal 20 circulation is an intricate vascular system emerging and remerging at the optic nerve head 21 (ONH). Tracing retinal vascular branching from ONH can allow detailed morphological 22 quantification, and yet remains a challenging task. We presented a robust semi-automatic 23 vessel tracing algorithm on human fundus images by an instance segmentation neural 24 network (InSegNN). InSegNN separates and labels i

Objective: To describe a patient with vitreous hemorrhage due to peripheral retinal ischemia and neovascularization, who was diagnosed with an underlying retinal arteriovenous malformation. Methods: A 15-year old girl presented with sudden-onset painless visual loss in the right eye. She underwent a full ophthalmologic wo

Retinopathy of prematurity (ROP) is a disorder affecting low birthweight, preterm neonates. In the preterm eye, the retina is not fully developed and neovascularization may occur at the margin between the developed vascular retina and undeveloped avascular retina. Without timely treatment by laser or intravitreal anti-vascular endothelial growth factor (VEGF) therapy, this can lead to tractional retinal detachment and blindness. Visualization of the retina in regular examinations by indirect

Across species, the optokinetic reflex (OKR) stabilizes vision during self-motion. OKR occurs when ON direction-selective retinal ganglion cells (oDSGCs) detect slow, global image motion on the retina. How oDSGC activity is integrated centrally to generate behavior remains unknown. Here, we discover mechanisms that contribute to motion encoding in vertically-tuned oDSGCs and leverage these findings to empirically define signal transformation between retinal output and vertical OKR behavior. W

Dark cone photoreceptors, defined as those with diminished or absent reflectivity when observed with adaptive optics (AO) ophthalmoscopy, are increasingly reported in retinal disorders. However, their structural and functional impact remain unclear. Here, we report a 3-year longitudinal study on a patient with oligocone trichromacy (OT) who presented with persistent, widespread dark cones within and near the macula. Diminished electroretinogram (ERG) cone but normal ERG rod responses together wi

Background: Alzheimer's disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The present work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) to determine the total retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL−F/NL−F mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT) animals.Methods: Total retinal thickness and RNFL thickness were

3 montaged gigh resolution OCT scans of the horizontal meridian, covering +/- 30 degrees eccentricity in the retina, and manual segmentations of the GCL and IPL.

Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of cellular function in the living eye, to study loss of vision in animal models of retinal disease, as well as evaluate the time course of retinal function following therapeutic intervention. We use high-resolution adaptive optics scanning light ophthalmoscopy to image fluorescence from the calcium sensor GCaMP6s. In mice with photoreceptor deg

Purpose: Spontaneous venous pulsation correlates negatively with elevated intracranial pressure and papilledema, and it relates to glaucoma. Yet, its etiology remains unclear. A key element to elucidate its underlying mechanism is the time at which collapse occurs with respect to the heart cycle, but previous reports are contradictory. We assessed this question in healthy subjects using quantitative measurements of both vein diameters and artery lateral displacements; the latter being used as th

High resolution OCT scans of the vertical meridian in the retina of 50 healthy subjects, with manual segmentations of the GCL and IPL.

ABSTRACT Vitreopapillary traction is an uncommon condition characterized by strong adhesion and the traction of the posterior hyaloid onto the optic disc and peripapillary retina, leading to optic disc elevation and visual loss. An 85-year-old man presented with a 6-month history of slow, progressive visual loss in the left eye along with optic disc edema. Swept-source optical coherence tomography B-scans revealed circumpapillary anterior-posterior persistent traction of dense vitreous strands o

ABSTRACT Vitreopapillary traction is an uncommon condition characterized by strong adhesion and the traction of the posterior hyaloid onto the optic disc and peripapillary retina, leading to optic disc elevation and visual loss. An 85-year-old man presented with a 6-month history of slow, progressive visual loss in the left eye along with optic disc edema. Swept-source optical coherence tomography B-scans revealed circumpapillary anterior-posterior persistent traction of dense vitreous strands o

ABSTRACT Wide-field angiography enables assessing peripheral areas with better quality and gives greater deep focus, which improves the image periphery. Some studies have proposed the usefulness of these angiographic systems in inflammatory diseases of the retina. However, few studies have evaluated this technique in Eales disease. We present a case series in which 5 eyes of 3 patients with Eales disease were evaluated by using retinal fluorescein angiography with 30º, 50º, and 150º lenses in a

Overview of the three ground truth data sets.

PurposeTo benchmark the human and machine performance of spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) image segmentation, i.e., pixel-wise classification, for the compartments vitreous, retina, choroid, sclera.MethodsA convolutional neural network (CNN) was trained on OCT B-scan images annotated by a senior ground truth expert retina specialist to segment the posterior eye compartments. Independent benchmark data sets (30 SDOCT and 30 SSOCT) were manually segment

To enable an objective evaluation of photocoagulation, we characterize thermal tissue changes induced by laser irradiation with different laser parameters using optical coherence tomography (OCT). Spectral-domain OCT with a newly developed image processing method was used to monitor the thermal changes of ex vivo porcine retina. A sequence of OCT B-scans was obtained at the same retinal position simultaneously with the photocoagulation. Cross-sectional tissue displacement maps with respect to an

PurposeTo identify the factors which significantly contribute to the thickness variabilities in macular retinal layers measured by optical coherence tomography with or without magnification correction of analytical areas in normal subjects.MethodsThe thickness of retinal layers {retinal nerve fiber layer (RNFL), ganglion cell layer plus inner plexiform layer (GCLIPL), RNFL plus GCLIPL (ganglion cell complex, GCC), total retina, total retina minus GCC (outer retina)} were measured by macular scan

This study presents TOM500, a comprehensive multi-organ annotated orbital magnetic resonance imaging (MRI) dataset. It includes clinical data, T2-weighted MRI scans, and corresponding segmentations from 500 patients with thyroid eye disease (TED) during their initial visit. TED is a common autoimmune disorder with distinct orbital MRI features. Segmentations of nine orbital structures, including the optic nerve, orbital fat, lacrimal gland, eyeball, and five extraocular muscles (superior rectus

Background: Symptomatic carotid artery disease (CAD) may cause modified blood supply to the retina possibly leading to retinal structure changes. Results of previous studies in asymptomatic CAD were heterogeneous in retinal layer changes measured by OCT. The objectives of this prospective, non-interventional study were to investigate if structural retinal changes occur in symptomatic CAD patients with macroangiopathic ischemic stroke or transient ischemic attack (TIA).Methods: We used spectral-d

ABSTRACT Wide-field angiography enables assessing peripheral areas with better quality and gives greater deep focus, which improves the image periphery. Some studies have proposed the usefulness of these angiographic systems in inflammatory diseases of the retina. However, few studies have evaluated this technique in Eales disease. We present a case series in which 5 eyes of 3 patients with Eales disease were evaluated by using retinal fluorescein angiography with 30º, 50º, and 150º lenses in a

Surgical microscopes are vital tools for ophthalmic surgeons. The recent development of an integrated OCT system for the first time allows to look at tissue features below the surface. Hence, these systems can drastically improve the quality and reduce the risk of surgical interventions. However, current commercial OCT-enhanced ophthalmic surgical microscopes provide only one additional cross sectional view to the standard microscope image and feature a low update rate. To present volumetric dat