Restoration of cone circuit functionality in the regenerating adult zebrafish retina
Version 1Unlike humans, teleosts like zebrafish exhibit robust retinal regeneration after injury from endogenous stem cells. However, it is unclear if regenerating cone-photoreceptors regain physiological function and integrate correctly into post-synaptic circuits. We used two-photon calcium imaging of living adult retina to examine photoreceptor responses before and after light-induced lesion. To assess functional recovery of cones and downstream outer retinal circuits, we exploited colour oppon
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Unlike humans, teleosts like zebrafish exhibit robust retinal regeneration after injury from endogenous stem cells. However, it is unclear if regenerating cone-photoreceptors regain physiological function and integrate correctly into post-synaptic circuits. We used two-photon calcium imaging of living adult retina to examine photoreceptor responses before and after light-induced lesion. To assess functional recovery of cones and downstream outer retinal circuits, we exploited colour oppon