General characteristics of the study population.
Version 1BackgroundBiomarkers are widely recognized as crucial breakthroughs in tackling amyotrophic lateral sclerosis (ALS). Among them, retina markers may hold promise due to the close retina-brain connection and non-invasive, portable detection methods. Thus, using optical coherence tomography (OCT), we investigated the link between baseline cell-level retinal features and future ALS risk.Methods and findingsParticipants from the UK Biobank underwent OCT scans to assess retinal layers, macula, and opt
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BackgroundBiomarkers are widely recognized as crucial breakthroughs in tackling amyotrophic lateral sclerosis (ALS). Among them, retina markers may hold promise due to the close retina-brain connection and non-invasive, portable detection methods. Thus, using optical coherence tomography (OCT), we investigated the link between baseline cell-level retinal features and future ALS risk.Methods and findingsParticipants from the UK Biobank underwent OCT scans to assess retinal layers, macula, and opt